Mouse anti-Human Chromogranin A (unconjugated), Clone LK2H10, IgG1, Ready-to-use

Ready-to-use Antibody for Immunohistochemistry

SKU:
E001
Category
Quantity
6 ml

Background

Hormone-producing organs and various hormone-producing cells in non-endocrine cells form the endocrine system. These hormone-producing cells are also referred to as the “diffuse neuro-endocrine system” (DNS)1, in which biogenic amines are both stored and decarboxylated (APUD concept)1. Although there are major functional differences among DNA cells due to the production of different hormones, they have in common the presence of chromogranin in the secretory granules.

Initially, chromogranin was identified as the major secretory protein of medullary chromaffin cells of the adrenal gland². However, in more recent immunohistochemical studies, it has been recognized as a widespread marker of almost all granule-containing endocrine cells and the tumors arising from them³-6. The behavior of tumor staining is proportional to the number of secretory storage granules present. Most endocrine tumors exhibit strong staining with the exception of small cell lung carcinoma, Merkel cell carcinoma, and neublastomas, which (with E001) assume only weak staining.

Synonyms

Chromogranin A

Reagent Description

  • Reagent Description List Item

Antigen

Antigen Description

Specificity

Specificity Description

Immunogen

Immunogen Description

Abnormal Tissue

Abnormal Tissue Description

Clone

Abnormal Tissue Description

Isotype

Isotype (Host Species – Isotype)

Application Description

Pretreatment

Pretreatment Description

Incubation Period

Incubation Description

Usage

Ready-to-use in PBS, BSA, NaN3 (0,09%) pH 7,4(*) suitable on cryostat sections (IHC-F) and on formalin-fixed, paraffin-embedded tissue sections (FFPE / IHC-P).

Control Tissue

Appendix or colon carcinoma

Recommended Secondary Reagents

Description Recommended Secondary Reagents

  • Reference List Entry Point

Specificity

Chromogranin A

Species Reactivity

Human, Monkey, Simian, Swine

Host / Source

Mouse

Isotype

IgG1

Application

IHC-F, IHC-P

Clone

LK2H10

Antigen

Human Chromogranin A

Quantity

6 ml

Format

RTU

Storage Temperature

2-8 °C

Shipping Temperature

20 °C

Documents

pdf Datasheet