Mouse anti-Human Leucocyte Common Antigen (LCA) (unconjugated), Clone 2B11+PD7-26, IgG1, Purified
Concentrated Antibody for Immunohistochemistry
CD45 is a transmembrane glycoprotein expressed on most nucleated cells of haematopoietic origin. CD45, encoded by a single gene mapped to chromosome 1, has various isoforms based on differential splicing of exons 4, 5 and 6. On human leucocytes, five different isoforms of CD45, named ABC, AB, BC, B and 0, have been identified. These isoforms are recognized by CD45RA, CD45RB, CD45RC and CD45R0 antibodies. The isoforms range in Mr from 180 000 to 220 000. All the CD45 isoforms share the same intracellular segment, which has been shown to have tyrosine phosphatase activity. Various leucocytes express characteristic CD45 isoforms, thus T cells express CD45 isoforms corresponding to
their development and activation, B cells predominantly express the ABC isoform, and monocytes and dendritic cells predominantly express the B and 0 isoforms. Granulocytes principally express only the B and 0 isoforms (4).
Leucocyte Common Antigen (LCA)
|Host / Source||
Human Leucocyte Common Antigen (LCA)
0, 5 ml